According to OpenAI, the integration of lab-in-the-loop optimization with autonomous labs and AI models such as GPT5 is transforming biological workflows. While GPT5 and similar models can generate innovative biological designs, OpenAI emphasizes that real progress relies on rapid experimental iteration. By closing the loop between AI-driven design and laboratory testing, organizations can accelerate the transition from promising concepts to practical results, creating new business opportunities in biotechnology and synthetic biology. As reported by OpenAI, this approach lowers protein synthesis costs and enhances efficiency across diverse research domains.